detailed description Composition: list of active substance(s) and other component(s): Each pipette contains: Fipronylpermethrin Butylhydroxyanisole (E320) Butylhydroxytoluene (E321) Excipients*Ephityx for very small breed dogs26.84 mg239.8 mg0.088 mg0.044 mgQSP 0.44 mlLephityx for small breed dogs67.1 mg599.5 mg0.22 mg0.11 mgQSP 1.1 mlLephityx for medium breed dogs134, 2 mg1199.0 mg0.44 mg0.22 mgQSP 2.2 ml Lephitix for large breed dogs268.4 mg2398.0 mg0.88 mg0.44 mgQSP 4.4 ml Lephitix for very large breed dogs402.6 mg3597.0 mg1.32 mg0.66 mgQSP 6.6 ml * Other components: benzyl alcohol, diethylene glycol monoethyl ether. yellowish solution. Indications: Used in dogs, in flea and/or tick infestations, when repellent action against sand flies and/or mosquitoes (bite protection) is also necessary. Fleas: Treatment and prevention of infestation with fleas (Ctenocephalides felis). Dog fleas die within 24 hours of treatment. A single treatment has a long-lasting effect against re-infestation with adult fleas for four weeks. The product may be included in the treatment scheme for dermatitis allergic to flea bites (DAPP), when the disease has already been diagnosed by a veterinarian. Ticks: Treatment of infestations with ticks (lxodes ricinus) A single application provides 4 weeks of continuous acaricidal activity against tick infestations (Ixodes ricinus, Dermacentor reticulatus and Rhipicephalus sanguineus). If Dermacentor reticulatus or Rirrplcephalus sanguineus species are present during application, not all may be killed within 48 hours. Sandflies and mosquitoes: single use provides repellent (bite protection) action against mosquitoes (Phlebotomus perniciosus) and (Culex pipiens, Aedes aegyptl) for four weeks. Target species: Dogs. Usage and dosage method: Intended for external use only. For local use. Dosage: The minimum recommended dosage is 6.7 mg of fipronil per kg of body weight and 60 mg of permethrin per kg of body weight. Dog weight Fipronil (mg) Permethrin (mg) 1.5 – 4 kg 26.82404 – 10 kg 6760010 – 20 kg 134120020 – 40 kg 268240040 – 60 kg 4023600 For dogs weighing more than 60 kg, use the appropriate combination of pipettes. Method of use: Remove the pipette from the blister. Hold in a vertical position. Tap the narrow part of the pipette to make sure that the contents have moved to the center of the pipette. Break the pipette along the self-breaking end along the engraved line. Pull the animal's fur until the skin is exposed. Place the tip of the pipette directly on the skin, carefully pressing it several times to completely empty the contents of the pipette, depending on the weight of the dog, in two to four places along the back between the shoulders and the base of the tail. For dogs weighing less than 20 kg, apply the product to two areas. For dogs weighing more than 20 kg, apply the product in 2-4 places. Therapeutic scheme: The product is used when an infestation is confirmed or there is a threat of infestation by fleas and/or ticks, and when repellent action against sand flies and/or mosquitoes (bite protection) is also required. Depending on the parasite impact, the vet may recommend repeating the treatment. The interval between two treatments should be at least 4 weeks. Side effects: skin reactions at the application site (itching, erythema, alopecia) and generalized itching have been reported very rarely. Behavioral changes (hyperactivity/agitation), neurological disorders (lethargy, muscle tremors, convulsions, ataxia) and vomiting have been reported very rarely. Transient hypersalivation may occur in case of alokvi. The frequency of side effects is determined as follows: Very common (side effects seen in more than 1 in 10 treated animals) Common (side effects seen in 1 to 10 animals out of 100 animals treated) Uncommon (side effects seen in 1 to 10 animals per 1,000 animals treated) Rare (side effects seen in 1 to 10 animals out of 10,000 treated animals) Very rare (side effects have been reported in less than 1 in 10,000 treated animals, including isolated cases). If you notice any side effects, even those not listed in this package insert, or if you think that the drug is not working, please inform your veterinarian. Contraindications: do not use in case of hypersensitivity to the active substance or any auxiliary substance. Do not use in rabbits or cats, as sometimes lethal side effects may occur (see also section "Special precautions for use in animals"). Do not use in sick animals (systemic diseases, fever, …) or convalescing animals