Detailed description Compound: 1 ml of the drug contains the active ingredient: Selamectin – 60 mg; Sarolaner – 10 mg. Excipients: dipropylene glycol monomethyl ether, isopropyl alcohol, butylated hydroxytoluene. Pharmacological properties: ATCvet QP55, endoctocides (QP544405, selamectin, macrocyclic lactates). Selamectin is a substance from the group of endoctocides of the class of macrocyclic lactones. The mechanism of action is associated with a change in the activity of chlorine channels in the synaptic membranes of the nervous and muscular systems of many ectoparasites. By binding to specific receptors, it increases the ionic permeability of synaptic membranes, which leads to a blockade of the electrical activity of nerve and muscle cells of parasites and, as a consequence, to their paralysis and death. In mammals, such receptors are located only in the central nervous system, since selamectin does not penetrate the blood-brain barrier, it has a high level of safety and is safe for dogs and cats at recommended doses. Selamectin exhibits a wide range of systemic nematicidal, insecticidal and acaricidal effects, and has larvocidal and ovicidal properties. The drug is quickly and completely absorbed into the blood from the site of application. The therapeutic concentration of selamectin in the blood is maintained for a long time, which ensures the destruction of parasites and protection against reinvasion for a month. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. The main target of action of Sarolaner on insects and ticks is the functional blockade of ligand-dependent chloride channels (GABA receptors and glutamate receptors). Sarolaner blocks GABA- and glutamate-dependent chloride channels in the central nervous system of insects and ticks. Disruption of these receptors by sarolaner prevents the uptake of chloride ions by GABA- and glutamate-gated ion channels, resulting in increased nerve stimulation and death of the target parasite. Sarolaner demonstrates a higher functional ability to block insect/acarid receptors compared to mammalian receptors. Sarolaner does not interact with known insecticidal nicotine binding sites or other GABA-active insecticides such as neonicotinoids, fiprols, milbemycins, avermectins and cyclodienes. Sarolaner is effective against adult fleas (Ctenocephalides spp.), as well as some species of ticks, such as Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus. Directions for use and dosage: Treatment of tick-borne disease for 5 weeks against Ixodes ricinus Ta Ixodes hexagonus, and also for 4 weeks against Dermacentor reticulatus Ta Rhipicephalus sanguineus. Prevention and treatment of otodectosis (Otodectes Cynotis), toxocariasis (Toxocara cati), hookworm (Ancylostoma tubeefortme), blood-sucking lice (Felicola subrostratus) and fleas (Ctenocephalides spp.), as well as for the prevention of dirofilariasis (Dirofilaria immitis). . The drug can be used as part of a therapeutic strategy for treating flea allergy dermatitis (FAD). The drug is used on dry skin between the shoulders in the following doses: Cats body weight, kg Pipette volume (ml) Selamectin (ml) Sarolaner (ml) ≥ 2.5 kg 0.25152.5 ≥ 2.5 – 5.0 kg 0.5305 ≥ 5.0 – 10.0 kg 16010
Destruction of fleas and ticks After 24 hours and within 5 weeks after taking the drug, adult fleas and ticks on the animal die. The drug interferes with the ability of fleas to lay viable eggs and destroys larvae in the environment. This breaks the flea breeding cycle and helps control contamination of the existing environment where the animal is located. To prevent infection, the drug should be used once a month during the flea and tick season. To use the drug as a component of therapy for flea allergic dermatitis, the drug is used at monthly intervals. Treatment of toxocariasis and hookworm A single dose of the drug must be used. The need and frequency of re-treatment should be agreed upon with the attending veterinarian who will prescribe the drug. Treatment of otodectosis The drug is used once. Before treatment, it is recommended to clean the ear canal of exudate and scars. If necessary, the course of treatment is repeated after a month. Treatment of pediculosis The drug is used once. Prevention of dirofilariasis To prevent dirofilariasis, Stronghold Plus is administered to animals monthly, a month before the start of mosquito/mosquito vector flight, and is completed no earlier than a month after the end of mosquito flight. If the monthly interval between two applications of Stronghold Plus is violated, the drug is used as soon as possible, which minimizes the possibility of the development of sexually mature heartworms. Heartworm