Simparica Chews for Dogs 22-44 lbs (10.1-20 kg) - Blue 3 Chews

What is Simparica?
Simparica is a fast-acting oral flea and tick preventative that begins killing fleas and ticks within hours of administration and remains effective for one month to prevent re-infestations. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)]. Simparica begins to kill adult fleas within 3 hours and ticks within 8 hours of administration. Treatment with Simparica may begin at any time of the year and is safe to use year-round without interruption. Simparica is given monthly.
For:
Dogs (over 6 months of age weighing 2.8+ lbs)
Benefits:

• Each tablet provides a full month of protection against fleas and ticks
• Tasty, liver-flavored chewable tablet is easy to administer
• Chewable tablets can be given directly to your dog or broken up and mixed with food
• Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs

How it works:
Simparica contains the active ingredient sarolaner, which inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Simparica is administered once a month directly by mouth or can be crumbled and mixed with food. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.
Cautions:
Not for use in humans. Keep this and all drugs out of reach of children and pets. For use in dogs only. Do not use Simparica in cats. Simparica should not be used in dogs less than 6 months of age weighing less than 2.8 lbs. The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.
Brand Name
Simparica
Generic Name
Sarolaner
Manufacturer:
Zoetis
What is this medication used for:
Simparica is used for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (Lone Star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] in dogs over 6 months of age weighing 2.8 lbs and over.
Availability:
Simparica is available as a liver-flavored, chewable tablet.
How this medicine should be used:
Simparica should be administered orally, once every month, at the minimum dosage of 0.91 mg/lb (2 mg/kg) sarolaner. Dogs weighing 2.8 to 5.5 lbs should be given one 5 mg Simparica chewable tablet monthly. Dogs weighing 5.6 to 11.0 lbs should be given one 10 mg Simparica chewable tablet monthly. Dogs weighing 11.1 to 22.0 lbs should be given one 20 mg Simparica chewable tablet monthly. Dogs weighing 22.1 to 44.0 lbs should be given one 40 mg Simparica chewable tablet monthly. Dogs weighing 44.1 to 88.0 lbs should be given one 80 mg Simparica chewable tablet monthly. Dogs weighing 88.1 to 132.0 lbs should be given one 120 mg Simparica chewable tablet monthly. Dogs weighing more than 132.0 lbs should be given appropriate combination of Simparica tablets monthly. Care should be taken that your dog consumes the complete dose, and treated pets should be observed for a few minutes to ensure that part of the dose is not lost or refused. If a dose is missed, administer Simparica and resume a monthly dosing schedule.
For flea treatment and prevention: Treatment may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with Simparica can continue the entire year without interruption. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with an approved flea control product.
For tick treatment and control: Treatment with Simparica can begin at any time of the year.
What are the side effects:
The most frequently reported adverse reactions were vomiting and diarrhea. Simparica may cause abnormal neurologic signs such as tremors, decreased conscious proprioception [awareness of body position and movement], ataxia [loss of full control of bodily movements], decreased or absent menace [blinking reflex], and/or seizures.
What special precautions are there:
The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs.
In the event of an overdose:
Contact your veterinarian immediately.
How should I store this medication:
Store at or below 86°F (30°C) with excursions permitted up to 104°F (40°C).
Directions:

• Administer one Simparica chewable once every month.
• Simparica may be offered by hand or broken into pieces and fed to dogs that normally swallow treats whole.
• Simparica chewables should be administered in a manner that encourages your dog to chew, rather than to swallow without chewing. Care should be taken to be sure that your dog consumes the complete dose.
• Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.