Previcox is a highly selective non-steroidal anti-inflammatory drug for dogs with a unique active ingredient firocoxib in tablet form. Composition Contains the following as an active ingredient: firocoxib - 24% (depending on the dosage, 57 mg and 227 mg per tablet, respectively), excipients: lactose monohydrate - 49.3%, microcrystalline cellulose -15%, hydroxypropyl cellulose - 3.0%, croscarmellose - 2.8%, colloidal silicon dioxide - 0.5%, flavorings and aromatic substances (flavoring agent with the taste of smoked meat "Chartor Hickory smoke flavor" and caramel) - 5%, pigments - yellow and red iron oxides - 0.4%. Features of the product: The most selective COX-2 inhibitor, allowing to provide excellent results. Safe for long-term use. Fast-acting, within 15 minutes after the first dose. Powerful pain relief 24 hours a day without a "failure" in pain relief. Steady growth in the degree of improvement of parameters with long-term treatment. Leads to an improvement noticeable to dog owners. A higher level of improvement compared to NSAIDs with a predominantly anti-inflammatory effect. Provides global control of the course of osteoarthritis with the highest degree of satisfaction of veterinarians and dog owners. In appearance, the drug is a brown tablet, round, convex, on one side of the tablet there is a score line and the engraving "M and dosage". The drug is stored in a sealed manufacturer's package, separately from food and feed, in a dry place protected from direct sunlight, at a temperature of 0 ° C to 30 ° C. The shelf life of the drug, subject to storage conditions, is 4 years from the date of manufacture. The unused half of the tablet can be stored in a blister for no more than 7 days.
Pharmacological properties Previcox tablets 57 mg and 227 mg belong to the group of non-steroidal anti-inflammatory drugs. Firocoxib, which is part of the drug, is a selective inhibitor of cyclooxygenase-2 (COX-2), selectively disrupts the formation of prostaglandins involved in the formation of an inflammatory reaction, suppresses the exudative and proliferative phases of inflammation. It acts mainly in the inflammation focus and has virtually no effect on the production of prostaglandins that regulate renal blood flow and the integrity of the gastrointestinal mucosa. It has analgesic, anti-inflammatory and antipyretic effects. After oral administration to dogs at the recommended dose, firocoxib is rapidly absorbed, the maximum concentration in the blood is achieved after 1.25 hours. The half-life is 8 hours. Firocoxib is almost completely bound to blood proteins, metabolized in the liver, excreted with bile through the intestine. Previcox tablets 57 mg and 227 mg are classified as moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76) in terms of their impact on the body; in recommended doses, they do not have a sensitizing, teratogenic or embryotoxic effect. Directions for use and dosage Previcox tablets 57 mg and 227 mg are prescribed to dogs as an anti-inflammatory, analgesic and antipyretic agent in the treatment of osteoarthritis, as well as after orthopedic, dental and soft tissue surgeries. Contraindications to use include increased individual sensitivity of the animal to the components of the drug (including in the anamnesis). It is prohibited to use the drug in pregnant and lactating females, puppies under 10 weeks of age and dogs weighing less than 3 kg, as well as animals with gastrointestinal bleeding, blood diseases, hemorrhagic syndrome and severe renal and hepatic failure. Previcox tablets 57 mg and 227 mg are used by dogs individually orally once a day at a dose of 5 mg of firocoxib per 1 kg of animal weight. Previcox tablets 57 mg and 227 mg have an attractive aroma and taste, so they are readily eaten by dogs, in case of refusal to take the drug, it is fed with food. The duration of the course of treatment for osteoarthritis depends on the condition of the animal and is determined by the attending veterinarian. The use of the drug for more than 90 days should be carried out under the regular supervision of a veterinarian. To relieve postoperative pain and inflammation in soft tissue surgeries, orthopedic and dental surgeries, the drug is used 2 hours before the surgery, and then, if necessary, once a day for 2-3 days. In case of drug overdose, the animal may experience excessive salivation, gastrointestinal upset, and depression. No special effects have been identified during the first use of the drug or when it is discontinued. Avoid violating the drug administration scheme, as this may reduce its effectiveness. If you miss a dose of the drug, its use should be resumed at the prescribed dosage and according to the same scheme. When using the drug in accordance with these instructions, side effects and complications in animals are generally not observed. Previcox tablets 57 mg and 227 mg should not be used simultaneously with other non-steroidal anti-inflammatory drugs and glucocorticosteroids. Marketing Authorization Holder: Boehringer Ingelheim Vetmedica GmbH, Germany. Manufacturer of finished product: Boehringer Ingelheim Animal Heads France SKS, France.